Information Visualization.
By using graphic elements to represent information and data, user could better understand the overall trend and summary of a dataset, a data analysis or information. You can always find interesting results when visualizing the data!
Invading Your Brain: Glioma
Data visualization | Graphic design | Information design
This data visualization shows the visual representation of clinical markers and genomic databases from glioma patient samples. It is used to explain the relationship between the biomarker MGMT gene, mutated gene frequency and the severity of a patient's glioma. The percentages of different subtypes of glioma are shown in bubble charts. The indication of MGMT status is explained on the left. The Alluvial diagram shows the correlations between MGMT status and cancer types to explain prognosis and survival outcome. On the right page, The top 42 mutated genes with the highest frequency in glioma patients are shown in the Chord diagram. The biological functions of the top 4 prominent mutation genes TERT, TP53, IDH1 and PTEN are briefly explained to the audience. This visualization provides an overview of the current genomic mapping of glioma patients to the audience to identify potential therapeutic targets in their research projects.
Use of media: Adobe illustrator and Tableau
Dataset: Jonsson P, Lin AL, Young RJ, et al. Genomic Correlates of Disease Progression and Treatment Response in Prospectively Characterized Gliomas. Clin Cancer Res. 2019;25(18):5537-5547. doi:10.1158/1078-0432.CCR-19-0032.
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Growing with the placenta
Data visualization | Graphic design | Information design
This data visualization work is showcasing the relationship between the growth of the fetus and the placenta. Placenta is a vital organ that helps the development of a fetus to obtain nutrients and excrete wastes. The health of a placenta largely affects a baby's growth in gestation. The aim of this piece of work is to reveal the relationship and educate the public audience about placental health.
Use of media: Excel, Adobe illustrator, Adobe Photoshop
Dataset: The Norwegian Mother, Father and Child Cohort Study, The Medical Birth Registry of Norway.
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Placenta (Background)
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Scientific infographic | Medical illustration | Information design
Superior Sagittal Sinus Thrombosis (SSST)
The purpose of this infographic is to depict the pathophysiology of Superior Sagittal Sinus Thrombosis (SSST). On the left upper corner, a description is given as an introduction to the disease, including the epidemiology, pathogenesis and the prognosis. The sagittal view of the brain showing central venous system is introduced as a small image on the left lower corner. The larger image shows the brain, with the thrombus blocking the Superior Sagittal Sinus. The tissue cube sequence reveals the morphological changes of the Superior Sagittal Sinus and the surrounding tissues from normal to terminal stages when the thrombus is forming within the sinus. Small descriptions are added to describe the pathogenesis of every stage.
This illustration helps educated lay audience to better understand the risk from having one of the rare form of stroke.
Use of media: Adobe Photoshop, Adobe Illustrator, Autodesk Maya, Osirix, Horos with CT/MRI data.
“This piece of work is presented and displayed at the annual conference of Association of Medical Illustrators (AMI).”
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Gray matter
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Thrombus
Scientific illustration | Information design | Vector graphics | Figure illustration
HBV-associated Hepatocellular Carcinoma (HCC)
I was tasked to create a vector-based illustration for a journal figure depicting mechanism of disease (MoD) of hepatocellular carcinoma (HCC).
Figure showing the pathway of HBV virus DNA integration and alteration of hTERT promoter region that are associated with HCC development. In a normal hepatocyte (green cell on the right), as it ages, telomere is shortened gradually due to cell division. If the length of the telomere goes over a critical length, it triggers the cell to undergo apoptosis.
References: 1. Wang, G. & Chen, Z. HBV Genomic Integration and Hepatocellular Carcinoma. Advanced Gut & Microbiome Research. 2022;2022:(1-7). doi:10.1155/2022/2140886. 2. Rizzo, et al. Hepatitis B Virus-Associated Hepatocellular Carcinoma. Viruses. 2022;14(5):986. doi:10.3390/v14050986.
Use of media: Adobe illustrator
Figure Description
1. In the cancerous hepatocyte (brown cell on the left), the virion of the HBV enters the host cell by binding the NTCP entry receptor on the cell surface.
2. It is enclosed and endocytosed by the endosome.
3. The viral rcDNA is carried to and enters the nucleus through nuclear pore complex.
4. The virus uses host cell DNA repair enzymes to convert rcDNA to cccDNA form.
5. cccDNA acts as the stable templates for viral mRNA transcription including the pgRNA.
6. pgRNA is then translated into rcDNA (major pathway) and dslDNA in the HBV nucleocapsid.
7. In the minor pathway, the 2 enhancers, enhancer I and II in HBV dslDNA causes the upregulation of hTERT proto-oncogene in/near TERT promoter region of Chromosome 5. Telomere formed by the overexpressed telomerase reverse transcriptase is extended beyond the critical length without undergoing a programmed cell death itself.
8. Nuclear dslDNA integrating into the host cell genome also produces high expressions of altered HBx proteins and HBsAg, which will lead to ER and mitochondrial stress responses.
9. Both processes will prevent the cancerous hepatocyte from apoptosis and thus continue the uncontrolled cell replication in the HCC development.
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Normal hepatocyte
Cancerous hepatocyte
Scientific illustration | Information design
Zooplate: Sally Lightfoot Crab
The zooplate illustration is focusing on Sally Lightfoot Crab, a very unique creature populated on Galapagos Island and Central America. Several perspectives of this colorful creature are shown, including species and habitat, lifespan and conversation and morphology. The purpose of this illustration is to create as a zooplate purpose in local park and aquarium, but also a way to practice gradient mesh in Adobe Illustrator.
Use of media: Adobe illustrator
Photo credit to: Jacob Hinkston
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Geographical location and anatomy
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